Americans who use proton pump inhibitors (PPIs) for heartburn, acid reflux, or ulcers face a possible increased risk of bone fractures, warns the Food and Drug Administration (FDA). The FDA says labeling on this class of drugs which includes popular prescription and over-the-counter medications such as Prilosec, Prevacid and Nexium that reduce stomach acid will be revised to include this risk. The FDAs actions follow its review of seven published studies, six of which reported an increased risk of fractures of the hip, wrist, and spine with PPI use. The greatest risk for these fractures was seen in those who receive high doses of these medications or use them for a year or longer. The FDA will work with the drug makers to further study the risk. As always, consult with your doctor before stopping or changing medications.